• March 6, 2024
  • Dr Peter Landsberg

Last updated on February 20, 2024

Rheumatoid Arthritis (RA) is a chronic autoimmune disorder that primarily affects the joints, causing inflammation, pain, and deformity. Researchers have found that there is a link between smoking and risk of RA, as well as the severity, and progression of RA. Here’s a guide to the relationship between smoking and rheumatoid arthritis, how smoking impacts risk of rheumatoid arthritis – and what you can do – from our clinic in Brisbane.

How Does Smoking Increase Risk of Rheumatoid Arthritis?

Smoking doesn’t just cause lung cancer and chronic obstructive pulmonary disease – numerous studies have provided compelling evidence suggesting a strong association between smoking and an increased risk of rheumatoid arthritis. The connection is particularly noteworthy among individuals with a genetic predisposition to the disease. Researchers have identified specific genetic markers, such as the HLA-DRB1 shared epitope, that interacts with smoking to elevate the risk of rheumatoid arthritis.

What is Behind Smoking and the Increased Risk of Rheumatoid Arthritis?

Tobacco and cigarette smoking has been shown to trigger a series of immune system responses that contribute to the development and exacerbation of autoimmune diseases, increasing your risk of rheumatoid arthritis. Here are some key mechanisms that increase your risk for developing rheumatoid arthritis:

  • Inflammation: Smoking is known to induce inflammation in the body, affecting various organs and systems. This can exacerbate the immune response, leading to increased joint damage and severity of symptoms in patients with rheumatoid arthritis.
  • Autoimmune Activation: Tobacco and cigarette smoking has been shown to promote the production of antibodies against citrullinated proteins (ACPAs), increasing your risk of rheumatoid arthritis. These antibodies are commonly found in individuals with rheumatoid arthritis and are associated with a more severe form of the disease.
  • Genetics: The interaction between genetic factors and smoking is a critical aspect of the smoking-rheumatoid arthritis connection. Certain genetic variations, especially within the HLA-DRB1 gene, appear to make individuals more susceptible to the risk of rheumatoid arthritis due to effects of smoking.

Clinical Implications of Smoking and Rheumatoid Arthritis

Recognising the link between all kinds of smoking, including cigarette smoking, and rheumatoid arthritis has significant implications for clinical practice, and smoking cessation programs should be integrated into care to help reduce the risk of rheumatoid arthritis and progression of the disease in patients with rheumatoid arthritis.

Moreover, for patients with rheumatoid arthritis, smoking cessation becomes a vital component of overall disease management. Studies have indicated that smokers who are rheumatoid arthritis patients tend to have poorer treatment outcomes and a reduced response to certain medications compared to non-smokers. Through smoking cessation, patients with rheumatoid arthritis may improve their response to therapeutic interventions, experience fewer complications, and enhance their overall quality of life.

Rheumatologist in Brisbane | Smoking and rheumatoid arthritis | Quit Smoking

Speak to an Experienced Rheumatologist in Brisbane

Looking for the expertise of a Rheumatologist in Brisbane? We offer more than just medical consultations; we provide a holistic and personal approach to treatment for all rheumatoid arthritis patients. With some of the most sought-after Rheumatologists in Queensland, patients with rheumatoid arthritis can be assured of receiving quality care tailored to your specific needs.

FAQs

Does smoking increase the risk of developing rheumatoid arthritis?

Yes, numerous studies have established that smoking is a risk factor for developing rheumatoid arthritis. Tobacco and cigarette smoking, particularly in those with a genetic predisposition, causes a higher risk of rheumatoid arthritis compared to non-smokers.

How does smoking contribute to the development of rheumatoid arthritis?

Smoking triggers inflammatory responses in the body and promotes the production of antibodies against citrullinated proteins (ACPAs), increasing your risk of rheumatoid arthritis.

Is there a specific genetic connection between smoking and rheumatoid arthritis?

Yes, certain genetic variations, particularly within the HLA-DRB1 gene, interact with smoking to increase risk of rheumatoid arthritis. The interplay between genetics and environmental factors like smoking plays a crucial role in the onset and severity of the disease in patients with rheumatoid arthritis.

Does smoking impact rheumatoid arthritis symptoms?

Yes, all smoking, including cigarette smoking has been linked to more severe symptoms and increased joint damage in patients with rheumatoid arthritis.

Can quitting smoking improve outcomes for rheumatoid arthritis patients?

Yes, smoking cessation can enhance the effectiveness of therapeutic interventions and overall disease management for patients with rheumatoid arthritis.

Are there specific smoking cessation programs tailored for individuals with rheumatoid arthritis?

Healthcare providers can educate patients about this risk factor for patients with rheumatoid arthritis and offer support for smoking cessation. Quitting smoking is considered a vital component of comprehensive disease management for patients with rheumatoid arthritis.

Dr Peter Landsberg

About The Author

Dr Peter Landsberg

Dr Peter Landsberg practices general Rheumatology with a special interest in inflammatory arthritis and connective tissue disorders. His holistic approach to medicine stems from the 12 years he spent as a GP before studying Rheumatology. On weekends you’ll find him trying (not always successfully) to stay upright on his mountain bike as he rides downhill tracks. Or out on Moreton Bay in his well-used tinnie, fishing with his family and the dog!

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